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Since GLP-1 receptors are located on a distinct set of appetite-regulating neurons in the brain, the combination of cagrilintide and semaglutide has the potential to further amplify appetite suppression [9]

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Collectively, these data uncovered a severe mitochondrial OxPhos dysfunction in pre-symptomatic Trkb Penk -KO mice, consistent with the RNA sequencing (RNA-seq) data and GSEA pathway analysis