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The vessel normalization hypothesis, introduced by Rakesh Jain in 2001 [308] suggests that rather than depleting vessels, a sub-maximal doses of anti-angiogenic therapy can restore the normal function and structure of tumor vessels and improve drug delivery
Nandi SS, Mishra PK
The general medical consensus, reflected in guidance from sources like GoodRx, Drugs.com, and major telehealth platforms, is that patients should limit or avoid alcohol while on tirzepatide, particularly during dose titration when GI side effects are most intense