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To date antioxidants including melatonin, ascorbic acid, and uric acid are yet to be applied to amphibian sperm cryopreservation extenders, and their potential to reduce sperm cryodamage is therefore currently unknown

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Although oral dosing may be a more appealing option versus parenteral administration for many patients and prescribing physicians [1216], mAbs are not amenable to oral dosing because they are prone to proteolysis and denaturation by gastrointestinal (GI) enzymes and generally have limited membrane permeability due to their large molecular weight (approximately 150 kDa) [1719]

doi: 10.1038/nrgastro.2017.109 57