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Osteoblast number on the surface of trabecular bone was observed by a histological analysis that demonstrated a significant increase after 16 weeks of exendin-4 use in OVX rats ( Glucagon-like peptide-1 promotes the expression of genes related to bone formation

doi: 10.1128/iai.69.6.4034-4040.2001 58 StoneKKBermudezEPryorWA

To attain the health benefits conferred by GLP-1s, it is critical that people prescribed GLP-1s continue to take them at least long enough to realize clinical success, and preferably longer to avoid possible weight rebound once they come off the medications

That is such a big number, its hard to wrap our heads around

Oral delivery of peptides faces inherent challenges due to enzymatic degradation in the gastrointestinal tract, and sublingual absorption offers a partial workaround by allowing the peptide to enter the bloodstream through the mucous membranes under the tongue

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