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Activates GLP-1 receptors in the hypothalamus, reducing appetite

Bioactive Materials, 32, 502-513

[60] History and clinical trials [edit] In the 1970s, Jens Juul Holst and Joel Habener began research on GLP-1, initially in relation to duodenal ulcer disease

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There are also questions about more serious risks, including blood clot concerns and pancreatic issues, though these remain rare

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