Cocaine and amphetamines (stimulants) All animal studies retrieved for stimulants misuse involved exendin-4 among GLP-1RAs and highlighted a reduction of cocaine and amphetamines intake and end effects (for example, increased locomotor activity) via modulation of dopaminergic transmission in areas including the nucleus accumbens and the ventral tegmental area 91,92,93,94,96,97,98,99,100,101,102,103,105 , as well as modulation of inflammatory mechanisms 104
This can be particularly noticeable if you already experience bloating as part of your IBS
Obesity and chronic kidney disease
But theres another part of the story that doesnt get talked about as much
The side effects have been mild, but worth it to lose weight
One of the most surprising facts about GLP-1 medications is that hypothyroidism by itself is not typically a reason to avoid them