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The market is becoming increasingly competitive as pharmaceutical and biotechnology companies accelerate investments in the development of differentiated oral GLP-1 receptor agonists

Vijayvergiya et al., 2005)

In addition to astrocytes and oligodendrocytes, microglia have been shown to be involved in ALS pathogenesis (Beers et al., In vivo imaging studies demonstrated increased microglia activation and inflammatory activity in spinal cord during symptomatic stages in the SOD1 G93A mouse model (Dibaj et al., G37R mice (Boille et al., High calorie diets in ALS A number of studies have tried to correct the energy deficit using metabolic therapies in animal models and patients with ALS, with the hope that an improved metabolism can delay symptoms and extend survival in ALS (Dupuis et al., 2006, 2012

Patient experience and anecdotal reports also can point to potential new uses

Cytokine 85 , 123129