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Common adverse effects include nausea, vomiting, diarrhoea, and constipation, which are generally most pronounced during dose escalation

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Some dosages of Zepbound are in limited supply through the end of April due to what the FDA describes on its website as "demand increase." Currently, the 5 mg and 12.5 mg doses of the drug have "limited availability." The FDA approved Zepbound in November as a weight loss management treatment for people with obesity, or those who are overweight with at least one related underlying condition, such as high blood pressure