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In the hospital settings, the implementation of GLP-1RAs may be particularly challenging, especially with once-weekly formulations, due to the potential need for discontinuation before surgical or diagnostic procedures or in the event of clinical deterioration

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Diabetes Care (2024), DOI - doi.org/10.2337/dci24-0003, Written by Vijay Kumar Malesu Vijay holds a Ph.D

Studies have found that up to 80% of PD patients may experience some form of cognitive impairment during the course of the disease [8]

After the success of peptide agonists of GLP-1R (a class B G-protein coupled receptor) in the treatment of diabetes, drug discovery scientists saw the opportunity for small molecule agonists of GLP-1R

Injectable tirzepatide (Zepbound) is FDA-approved and backed by large clinical trials showing average weight loss of over 20% in participants on the highest dose