glp-1 gip vs tirzepatide Semaglutide Tirzepatide: 7 Best Proven Facts 2026 Major physiological roles of GLP-1

Electrolytes Electrolytes deserve mention because the fluid shifts and dietary changes on tirzepatide can deplete sodium, potassium, and magnesium quickly, leading to headaches, muscle cramps, and that draggy feeling

Higher-dose and longer-duration programs deliver significantly better per-milligram value

This hormone plays an important role in regulating blood sugar levels and appetite

Adding tirzepatide further reduces dietary intake

Across all dose groups the hair-loss rate was around 5%, compared with roughly 1% on placebo

Standard protocols maintain weekly dosing for consistent effects, though microdosing schedules offer alternative approaches for those seeking lower overall exposure