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Finally, even minor changes in drug absorption may be clinically significant in the context of drugs with a narrow therapeutic index

For instance, reduced expression of PER1 and CRY1 has been associated with higher tumor grade and poor prognosis 27

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Protein carbonyls have been found to be elevated in Alzheimers diseases, diabetes, renal diseases, and other disorders (Gil et al

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A protocol that looks efficient on paper but compresses titration intervals will almost certainly produce worse outcomes than a patient, methodical escalation