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The future of GLP-1 research As GLP-1s continue to reshape the treatment of type 2 diabetes and obesity (along with an expanding list of potential indications), real-world evidence will be essential for optimizing their use, ensuring access, and tailoring treatments to the individual needs of patients

However, a recent 12-week multicenter study comparing the efficacy of GLA (320 mg/day) and ALA (600 mg/day) in participants with T2D and painful DPN found that after 12 weeks, both neuropathic symptoms and pain improved, and GLA was shown to be non-inferior (equally effective) to ALA in reducing pain intensity [115]

Islet experiments were performed by at least two different investigators, one of them being blinded for the experimental measurement for GSIS

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