La mayor prdida de peso se inform en un RCT de retatrutide (12 mg una vez por semana), un agonista triple dirigido a los receptores de GLP-1, GIP y glucagn que an no est aprobado por la FDA o disponible comercialmente
However, most studies have focused on specific patient subgroups, limiting the generalizability of the findings to the broader population of individuals with obesity
Less common but serious adverse effects seen in the clinical trials are pancreatitis (inflammation of the pancreas), gallbladder disease (such as gallstones), and worsening of diabetic retinopathy
With type 2 diabetes, a persons insulin either doesnt work properly, or there is not enough of it, causing blood sugar levels to become too high (2)
Among the 56 patients with complete follow-up data at 1 year, there was a significant improvement in weight-related comorbidities, including a reduction in obstructive sleep apnea syndrome ( 30%), hypertension ( 40%), arthralgia ( 56.5%), and fatty liver disease ( 36.4%)
Daldal F