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Free B12 then binds to R-proteins secreted by salivary glands

Bioorg Med Chem 2018;26, 3925-3938, doi:10.1016/j.bmc.2018.06.013

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concurrent tobacco smoking further augments thrombotic risk, and careful monitoring is advised when estrogens are co-administered with thyroid hormones, corticosteroids, or anticoagulants due to possible alterations in binding protein levels and pharmacodynamic response