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In the latter, previous reports have shown that GLP-1R is involved in NO-mediated suppression of intestinal motility 33

[3] Naver S, Jimenez-Solem E, Christensen M, et al.Dulaglutide: a novel once-weekly glucagon-like peptide-1 receptor agonist[J].Clinical Investigation, 2014, 4(8): 729-743

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GLP-1RAs work in a similar way to glucagon-like peptide-1 (a natural peptide hormone produced by cells in the intestine and in part of the brain), regulating blood sugar levels and appetite