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Description

Fast-forward a couple of decades, and now we have multiple GLP-1 medications and one dual GLP1/GIP medication with unique profiles in the market that can help optimize patient outcomes

The newer Foundayo (orforglipron), FDA approved April 2026, is the first oral GLP-1 with no food or water restrictions although average weight loss is lower than the injectables (11% vs 15-20%)

Common adverse effects include gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation), which are usually transient and dose-dependent

Ozempic | European Medicines Agency (EMA)