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[5] Zhang L, et al

Lactate-HIF-1a axis promotes PINK1-dependent mitophagy to protect porcine granulosa cells against hypoxic stress

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The progressive decline in mitochondrial function, characterized by impaired ATP synthesis, excessive ROS production, and structural abnormalities, triggers a vicious cycle involving energy crises, oxidative stress, and inflammatory responses, ultimately accelerating cardiomyocyte death [129, 130]

Being underweight and having a low body fat percentage ( 15 mol/L), 56% had low B12 status, and 88% had intracellular folate levels lower than those believed to be optimal for preventing neural tube defects