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Evaluar respuesta al tratamiento (peso, HbA1c) cada 4-12 semanas durante la titulacin

Use of drugs that inhibit organic cation transporter 1 activity (including tricyclic antidepressants, citalopram, proton-pump inhibitors, verapamil, diltiazem, doxazosin, spironolactone, clopidogrel, rosiglitazone, quinine, tramadol and codeine) increased intolerance to metformin (72)

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In female rats, supplementation with spirulina platensis (P41-P55) reversed the POS-induced depressive-like behavior in the FST at P60-P70 [144]