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Though not examined in this study, NO has been shown to inhibit NOX activity through s-nitrosylation

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The most common side-effects of the medicine are gastrointestinal such as nausea, diarrhoea, constipation and vomiting

Unlike single-target pharmaceuticals, berberine affects multiple molecular pathways simultaneouslywhich makes it pharmacologically interesting but difficult to characterize simply

The fragment based approach significantly reduced aggregation and process-related impurities, resulting in substantial improvement in yield and purity compared with conventional stepwise peptide elongation protocols, thereby demonstrating an efficient and robust strategy for Semaglutide synthesis