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The next logical step would be a prospective, biomarker-stratified, randomised trial in patients with decompensated ALD with evidence of high systemic inflammation, enriched for high CRP/NLR and preserved albumin, with glutathione versus placebo on top of standard care, and with MELD-3 trajectory, CRP change and pragmatic clinical outcomes as endpoints
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This delayed absorption, combined with the medications' known side effects, may increase the likelihood of nausea, vomiting, or abdominal discomfort
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doi: 10.1186/s40529-014-0063-5 33 de Torres-ZabalaM.TrumanW.BennettM
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