GLP-1 receptor agonists work by mimicking a naturally occurring gut hormone that regulates blood glucose, reduces appetite, and promotes weight loss
However, we disagree with their recommendation because positive and negative payment adjustments are based off of numerous factors beyond the cost performance category
Meneilly GS, Ryan EA, Radziuk J, Lau DC, Yale JF, Morais J, Chiasson JL, Rabasa-Lhoret R, Maheux P, Tessier D, Wolever T, Josse RG, Elahi D: Effect of acarbose on insulin sensitivity in elderly patients with diabetes
This side effect occurs because GLP-1 slows gastric emptying and reduces appetite-driven motility, fundamentally altering digestive transit time and bowel frequency
However, the lower bioavailability may require higher doses or longer treatment periods to achieve comparable results, if achievable at all
Some users report mood swings, irritability, anxiety, or mild depression