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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
In the brain, excess ferrous iron can potentially disrupt the activity of both DNA methyltransferases (DNMT) and ten-eleven translocation proteins (TET) enzymes, impairing the DNA methylation and demethylation processes that regulate gene expression (Zhao et al., 2014)
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Pain behaviors in these rats and the time course of mechanical hyperalgesia are similar to patients pain reports in the postoperative period [12]
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