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included 101 prediabetic T2D patients with MASH and randomized them to pioglitazone or placebo groups

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Despite the promising preclinical evidence regarding the efficacy of these natural compounds, translating the findings into clinical practice remains limited by several challenges, including issues related to bioavailability, optimal dosing, standardization of extracts, and the need for well-designed clinical trials to validate the efficacy and safety of the therapies in diverse asthma phenotypes