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Catechin and its derivatives are the main functional components in tea and many studies have shown that the effects of catechin on mitochondria-related pathways can prevent neurodegeneration and delay the decline of brain function ( Caenorhabditis elegans strains that express amplified ATX3 (amyloid) toward non-toxic aggregation and prevent calcium influx-mediated cytotoxicity of nerve cells (Visentin et al., 2017)