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Dose-Dependency: As suggested by the authors of the report and seen in Case 2, this adverse reaction appears to be dose-dependent , emerging at higher therapeutic doses

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Schlattner, U., Tokarska-Schlattner, M

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The instrument was employed in negative ion chemical ionization mode and a 15-m Rtx-5Sil MS W/Integra Guard capillary column (Restek) with a 0.25-mm inside diameter, and 0.1-m film thickness was employed for analyte resolution