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This is a clinically important interaction that requires awareness, particularly in perioperative settings

Acknowledgements We are thankful for the support from the National Key Research and Development Program of China (2025YFE0107400), National Natural Science Foundation of China (82341232, China), the Future Network (083GJHZ2023012FN), and Grand Challenges (083GJHZ2023021GC) of the International Partnership Program of the Chinese Academy of Sciences, CAS Presidents International Fellowship Initiative (2024VBB0004), Overseas Base Project of CAS, and High-level Innovative Research Institute (2021B0909050003), and Zhongshan Municipal Bureau of Science and Technology (LJ2021001)

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7 Clinical outcomes of pharmacotherapy To date, numerous clinical studies including double- or single-blinded randomized clinical trials and split-face studies have been conducted to assess the therapeutic effect of various topical conventional and novel formulations in melasma management as summarized in Table 3