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Molecular chaperones are one of most primary post-translation modifications involved in protein synthesis and folding of polypeptides to pass into organelles and the ubiquitinproteasome system (UPS) for induction of autophagy
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The side-effects of GLP-1s are predominantly gastrointestinal, including nausea, vomiting, heartburn, and gastroparesis (stomach slowing or paralysis) all symptoms which cause acid reflux
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A short course of GLP-1RA treatment not only promotes weight loss but also appears to redistribute fat deposits, which may help improve cardiovascular risk in patients with type 2 diabetes [50]
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