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These sites are cleaved by the AP endonuclease, APE1, and corresponding nucleotides are then located into the gap by a DNA polymerase through two different sub-pathways, to finally be ligated by a DNA ligase (Krokan and Bjoras, 2013)
Using cultured rat adipocytes experiments demonstrated that chronic exposure to both insulin and glucose was required for the adipocytes to become insulin-resistant
Although HDACs are now recognized to regulate diverse PTMs, they were initially defined by their ability to remove acetyl groups from histone tails