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Hmg-coa reductase inhibitors induce apoptosis of lymphoma cells by promoting ros generation and regulating akt, erk and p38 signals via suppression of mevalonate pathway

10.18632/oncotarget.10415 305 WuC

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In the HG-3 and MEC-1 cell lines, after the normalizing radioactivity (in disintegrations per minute) to the cell counts, we did not observe any decreases in thymidine or uridine incorporation after 72 hours of incubation with CB-839 at any dose

Antioxidant enzyme activity 20, 40, 60, and 90 mM salt treatments significantly (p 0.001) increased SOD activity by 10%, 19%,42%, and 49%, CAT activity by 11%, 15%, 33%, and 34%, APX activity by 27%, 60%, 73%, and 74%, GPX activity by 31%, 44%, 66% and 72%, respectively, relative to with respect to those in untreated Mentha piperita plants (Fig