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GST A1/A1 is a homodimer, GST B1/B2 is a heterodimer

Mechanistic Comparison# Dosing Comparison# Amycretin Dosing# Amycretin dosing is investigational: Subcutaneous: Once-weekly injection, doses up to 60 mg studied in phase 1b/2a over 36 weeks Oral: Daily tablet, doses up to 50 mg (or 2 x 50 mg) studied in phase 1 Phase 2 T2D: Both subcutaneous and oral formulations studied over 36 weeks Phase 3 dose selection will be informed by the completed phase 2 data

Why did the AOD 9604 clinical trials fail

Areas of application: Vitamin B12 deficiency that cannot be remedied with nutrition

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