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More importantly, autophagy indeed plays a bi-modal role in melanoma growth at different clinical stages, namely, tumor suppressor at early stage but tumor promoter at advanced stage

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However, the de-pigmenting effects at the presence of 0.1, 1 and 10 mM of -arbutin are individually much lower than that of 50 M T1

Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H

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We focus on metabolism, muscle retention, and long-term sustainability