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The second cost significance requirement, at 419.66(d)(2), provides that the estimated average reasonable cost of the devices in the category must exceed the cost of the device-related portion of the APC payment amount for the related service by at least 25 percent, which means that the device cost needs to be at least 125 percent of the offset amount (the device-related portion of the APC found on the offset list)

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The clinical benefit of liraglutide 3.0 mg was mostly mediated by its effect on BW, as treatment assignment was not associated with change in AHI independently of weight reduction 20

The dual GLP-1/GIP mechanism creates potent metabolic effects at lower doses than single-target agonists