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They signal the pituitary to release the patients own growth hormone in a pulsatile pattern that mirrors physiology, which is the mechanism we use when we talk about peptides for hormone balance

Barrett FS, Doss MK, Sepeda ND, Pekar JJ, Griffiths RR

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Taking the stomach minute lesions presentation as the outcome, we offer novel evidence for how cytoprotection/adaptive cytoprotection instantly functions in the stomach from tongue (first target), and then esophagus-stomach-duodenum chain of events, and impaired lower esophageal and pyloric sphincter

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doi: 10.1021/acs.jafc.7b05913