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It has a direct inhibitory effect on the HPI axis, leading to reduced cortisol release
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Kirkland, Identification of a novel senolytic agent, navitoclax, targeting the Bcl2 family of antiapoptotic factors
These resistance-associated genes also overlapped with those identified in an additional genetic screen seeking to identify drivers of estrogen-independence - with CSK also as a shared top hit suggesting that the identified genes are relevant for general endocrine resistance (and perhaps G1 arrest), rather than representing a giredestrant-specific resistance program 36
Thus, although T cells, macrophages, and dendritic cells (DC) each have significant plasticity to engage in other metabolic pathways for energy generation, survival, and proliferation, these changes alter or impair immune function
