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A clinical proof-of-concept trial used 0.03 mg/kg twice daily for short durations and found the drug to be generally well tolerated, though efficacy endpoints were mixed depending on the indication

In temporal lobe epilepsy, levels of astrocytic glutamate transporters in hippocampus are reduced by up to 40%

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These new agents, along with Rho-associated kinase (ROCK)2 inhibitors like KD025, which modulate inflammatory responses by targeting Th17 cells, represent a significant leap forward in psoriasis therapeutics (Zanin-Zhorov et al

Aim for the middle or back shelf where temperature remains most stable