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Standard oral glutathione is susceptible to gastrointestinal peptidase cleavage, limiting absorption from single doses
Lau DCW, Erichsen L, Francisco AM et al (2021) Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial
A critical consideration is that rapid weight loss from any causewhether through medication, surgery, or lifestyle modificationis associated with bone density reduction, making it challenging to isolate the independent effect of GLP-1 medications from the effect of weight loss itself
However, the "precursor" route is not the only way