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In contrast, thyroxine (T4) may elicit pro-fibrotic effects through non-genomic signaling via integrin v3, activating Rho-dependent pathways that induce -SMA and p75 neurotrophin receptor (p75NTR) expression in HSCs (99)

NLCs were designed specifically to address some limitations of the first-generation SLNs- such as limited loading capacity and the tendency of some active compounds to be expelled from the solid lipid matrix during storage

Maintenance phase: Some practitioners drop to 250 mcg every other day during maintenance phases to sustain modest lipolytic tone without driving full receptor engagement daily

10.1136/hrt.54.3.258 92 HowarthS.McMichaelJ.Sharpey-SchaferE

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