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Revolutionizing GLP-1 delivery with sublingual administration Recently, a new sublingual modality for GLP-1 receptor agonists (and also for insulins) delivery has been developed by the Dutch company SUBLIN BV, established in 2018 as a spin-out of the healthcare branch of NanoServe BV

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doi: 10.1016/j.bbrc.2009.12.075

GLP-1 and GIP receptors affect appetite, insulin sensitivity, and satiety

The satiety effect appears to be mediated through episodic meal-related signals rather than tonic appetite suppression, with pramlintide reducing meal size and duration without affecting meal frequency