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Unopposed antidepressant therapy is known to lead to manic switch in a modest proportion of bipolar disorder patients (Gorwood et al., 2016), but this does not occur in the context of a mood-stabilizer or neuroleptic use (Post et al., 2003), with attention being paid to the subgroup of patients susceptible to antidepressant-induced manic switch
Furthermore, the two groups had no evidence of a difference in mortality rate (HR 1.06
[DOI] [PubMed] [Google Scholar] Salic K., Gart E., Seidel F., Verschuren L., Caspers M., van Duyvenvoorde W., Wong K.E., Keijer J., Bobeldijk-Pastorova I., Wielinga P.Y., Kleemann R
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Asian J Psychiatry
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