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Toxicol Pathol 38(3):346358

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and naltrexonebupropion (Mysimba), which requires particular caution because fluoxetine is a potent inhibitor of the liver enzyme CYP2D6 and can increase bupropion levels, raising the risk of seizures and neuropsychiatric effects

However, thorough assessment of the CNS of the Lurcher mice focused e.g., on potential mild morphological, cellular, biochemical changes, or gene expression are needed to verify whether the mutation does not primarily affect other structures

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