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The translocated cyt c hijacks histone chaperones such as suppressor of variegation, enhancer of zeste and trithorax (SET)/template-activating factor (TAF)-I, inhibiting the nucleosome assembly/disassembly activity and DNA repairing ( c has also been identified as one of the components of brainstem Lewy bodies (Wakabayashi et al., 2007) and might play as a trigger in -Syn aggregation (Hashimoto et al., 1999)

male, n = 40

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All preclinical safety information comes from animal studies, which may not fully predict human responses