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Despite an identical N-terminal histidine in GLP-2, GLP-1 and glucagon, the side-chain orientations of histidine in the cognate receptors are different: the GLP-2 His 1P is more distant from TM5 than that of GLP-1 and closer to TM3 than that of glucagon (Figs

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Rectal bleeding whilst taking Ozempic requires prompt medical assessment to exclude haemorrhoids, inflammatory bowel disease, polyps, or colorectal cancer

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Data synthesis and analysis The comparison of outcomes among the different glucose-lowering drug classes was made using a frequentist approach for direct and indirect treatment comparisons for each endpoint [19]