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However, Januvia requires dose adjustment in patients with renal impairment specifically, a reduction to 50 mg for eGFR 3044 and 25 mg for eGFR below 30

Given the functional synergy and complementary mechanisms between GLP-1R and GIPR, therapies targeting both GIPR and GLP-1R activation have emerged as promising approaches for obesity and type 2 diabetes treatment to improve weight loss and metabolic outcomes