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Several membrane-bound proteins suggested to play a role in this process include CD73, able to convert NMN into NR 67 , and NAD + glycohydrolases such as CD38 that convert NAD + into NAM and ADP-ribose
This pathway supplies essential metabolites, R5P for nucleotide biosynthesis and cell proliferation, and NADPH for antioxidant defenses
Cervilla et al., 2007)
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80,102 Very interestingly, CD38-KO mice showed increased longevity and were protected against NAD level decreases associated with age, indicating that other NAD-consuming enzymes may play an important role in age- and age-dependent diseases
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