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Rapid weight loss causes skin laxity because it results in loss of volume, which is why GLP-1 users who have lost weight quickly find it can be especially noticeable. SkinMedicas targeted neck cream helps firm sagging neck skin with a blend of peptides, green microalgae, rice protein and shiitake mushroom extract

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43 Cardiovascular outcomes data are awaited from the SURPASS CVOT trial (clinical trial number NCT04255433

It also affected proliferation and differentiation in keratinocytes

Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6