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Determining the roles of, particularly, ABCG2 and GLUT9 in glia and neurons, how they respond to inflammatory challenge, to cellular activation, and to variation in UA concentrations is essential to understanding the disposition and activity of UA in the CNS

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thus, its variability has the potential to confound data interpretation

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Animal studies further demonstrate that female offspring of male mice fed a high-fat diet exhibit early pancreatic dysfunction and impaired glucose tolerance, highlighting the intergenerational metabolic consequences of paternal diabetes [102]