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Safety, Monitoring, and Eligibility Considerations Orderly Meds Review includes built-in safety screens for contraindications: personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, acute pancreatitis, severe renal impairment, and active diabetic retinopathy progression

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Fifty-one percent (51%) (48/95) of subjects in the low maintenance dose group dose-escalated, and 38% (35/93) of subjects in the high maintenance dose group dose-escalated

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The choice between tretinoin and isotretinoin hinges on the acnes severity and the patients skin goals