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[82] Lindson N, Theodoulou A, Ordez-Mena JM, et al

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They do not appear to silence mast cells directly but instead shield the surrounding neurons from their inflammatory impact, preserving communication in the gutbrain axis

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A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]