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Our network metaanalysis aimed to compare cerebrovascular benefits among glucose-lowering treatments

Mandal AH, Ghosh S, Adhurjya D, Chatterjee P, Samajdar I, Mukherjee D, et al

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Clinically, this results in increased blood pressure and heart rate due to unopposed sympathetic stimulation

PMID: 24893280

To try to visually grasp why the differences happen, heres a good chart from George Kellys work, titled On the synthesis of coenzyme forms of B12: So, which is the best type of B12