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Some employer plans may not offer the pills at all While the GLP-1 pills are priced essentially the same as injectables, trials show they are less effective for weight loss

Nausea and vomiting (common when starting the medication but usually temporary) Diarrhea or constipation Mild fatigue or dizziness Loss of muscle mass if weight loss is too rapid A study published in JAMA found that GLP-1s significantly reduce body weight and A1C levels (a marker of blood sugar control) in older adults

Nausea, vomiting, diarrhea, and severe appetite suppression can become unbearable at higher tirzepatide doses, particularly at 10 mg, 12.5 mg, and 15 mg

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I 2 = 27%) compared with metformin, but not for HbA1c (MD: -0.05, 95% CI: -0.19, 0.09